Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis
Q Zhou, Y Mei, T Shoji, X Han, K Kaminski, GT Oh… - Circulation, 2012 - Am Heart Assoc
Background—Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The
Rho-associated coiled-coil-containing kinases (ROCK1 and ROCK2) are serine-threonine
protein kinases that are involved in the regulation of the actin cytoskeleton. Recent studies
suggest that ROCK1 in macrophages and bone marrow–derived cells mediates
atherogenesis. However, a similar role for ROCK2 in the pathogenesis of atherosclerosis …
However, the signaling pathways that regulate their function are not well understood. The
Rho-associated coiled-coil-containing kinases (ROCK1 and ROCK2) are serine-threonine
protein kinases that are involved in the regulation of the actin cytoskeleton. Recent studies
suggest that ROCK1 in macrophages and bone marrow–derived cells mediates
atherogenesis. However, a similar role for ROCK2 in the pathogenesis of atherosclerosis …
[HTML][HTML] ROCK2 Deficiency in Bone Marrow-Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis
Q Zhou, Y Mei, T Shoji, X Han, K Kaminski, G Taeg… - Circulation, 2012 - ncbi.nlm.nih.gov
Background Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The
Rho-associated coiled-coil containing kinases (ROCK1 and ROCK2) are serine-threonine
protein kinases that are involved in the regulation of the actin cytoskeleton. Recent studies
suggest that ROCK1 in macrophages and bone marrow (BM)-derived cells mediates
atherogenesis. However, a similar role for ROCK2 in the pathogenesis of atherosclerosis …
However, the signaling pathways that regulate their function are not well understood. The
Rho-associated coiled-coil containing kinases (ROCK1 and ROCK2) are serine-threonine
protein kinases that are involved in the regulation of the actin cytoskeleton. Recent studies
suggest that ROCK1 in macrophages and bone marrow (BM)-derived cells mediates
atherogenesis. However, a similar role for ROCK2 in the pathogenesis of atherosclerosis …
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